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IHSA Compliance of Certified Hydrogen Water Bottle

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The Necessity of Molecular Hydrogen Therapy for Individuals


What is Free Radicals

Free radicals, also referred to as free radical species, are defined as atoms or groups of atoms possessing unpaired electrons. These entities are generated when the covalent bonds within a compound's molecules break evenly due to external influences such as light or heat. In scientific notation, a dot (·) is typically placed adjacent to the atomic or group symbol to signify the presence of unpaired electrons. Notable examples of free radicals include the hydrogen radical (H·), which represents a hydrogen atom; the chlorine radical (Cl·), indicative of a chlorine atom; the hydroxyl radical (OH·); the methyl radical (CH3·); and the tetramethylpiperidine N-oxide radical, among others. 

"Free radicals" are byproducts generated during the metabolic process of oxygen within the human body. These substances are characterized by their high reactivity, enabling them to engage in vigorous interactions with various materials. As unstable entities, free radicals possess the potential to inflict cellular damage, which can contribute to the onset of diseases and the aging process. In response to the presence of pathogens such as bacteria, fungi, or viruses, the immune system activates phagocytic cells to mount a defense. These phagocytic cells, through the action of specific enzymes, generate "superoxide anion free radicals" to target and eliminate the offending microorganisms or infected cells. Thus, a certain level of free radicals is essential for the body's defense mechanisms against diseases. Ideally, the concentration of free radicals within the human body should be maintained in a state of equilibrium.

However, exposure to various environmental stressors, including ultraviolet radiation, electromagnetic fields, tobacco smoke, pesticides, air pollution, as well as lifestyle factors such as irregular habits and psychological stress, can lead to an overproduction of free radicals, also referred to as oxidants. When the quantity of free radicals surpasses the normal defensive threshold, a "free radical chain reaction" may ensue, resulting in the oxidation of fundamental cellular components such as proteins, carbohydrates, and lipids. This process generates additional free radicals, which perpetuate the cycle of oxidation, ultimately compromising cellular integrity and function, and contributing to the development of various diseases.

While proteins in the body can facilitate the repair of damage inflicted by free radicals, cellular fatigue may hinder the effective elimination of these reactive species and the clearance of oxidative waste products. As a result, cumulative damage may manifest in symptoms associated with organ aging, physical decline, skin laxity, and diminished immune function.

Harmful of Free Radicals

Research within the medical field has identified eight mechanisms through which excessive free radicals can inflict oxidative damage on the body:
1. Inducing breaks in DNA strands or altering base structures, thereby damaging genetic material.
2. Causing lipid peroxidation through the destruction of unsaturated fatty acids.
3. Oxidizing protein molecules and inactivating serum anti-proteases by affecting internal enzymes.
4. Provoking abnormal responses in mononuclear leukocytes and macrophages, leading to the release of inflammatory mediators and the initiation of inflammatory processes.
5. Compromising periodontal tissues by degrading osteoclasts and the bone matrix at the bone interface.
6. Resulting in cellular deterioration, deformation, and death through lipid oxidation, which accelerates the aging of tissues and organs.
7. Directly affecting the cell nucleus, potentially causing gene mutations that may lead to cancer.
8. Inflicting damage on vital organs such as the heart, liver, and lungs, as well as on blood vessels.

Molecular hydrogen (H2) serves as a highly effective selective antioxidant

Hydrogen gas (H2) has the capability to selectively eliminate certain toxic reactive oxygen species (ROS), including hydroxyl radicals (•OH) and peroxynitrite anions (ONOO-), while leaving unaffected those ROS that exert physiological effects, such as hydrogen peroxide (H2O2) and nitric oxide (NO-).

Molecular Hydrogen Therapy

Professor Naruo Ohta of Nippon Medical University has conducted research that substantiates the selective antioxidant properties of hydrogen. His findings indicate that hydrogen can effectively and selectively neutralize detrimental free radicals, which are implicated in various diseases and the aging process. This mechanism contributes to the maintenance of internal environmental equilibrium at the fundamental cellular fluid level within the human body, stimulates the body's intrinsic self-repair processes, and enhances overall health outcomes.

Hydrogen Medicine Study In China

Since 2007, the field of hydrogen medicine has experienced significant global advancement, with China being a notable contributor. According to preliminary data, there are over a thousand researchers in China dedicated to the study of hydrogen medicine, including more than ten academicians from the Chinese Academy of Sciences and the Chinese Academy of Engineering. Additionally, there are over 80 projects funded by the National Natural Science Foundation that pertain to hydrogen medicine. On an international scale, more than 1,800 scholarly articles have been published in this domain, with nearly half originating from China. Furthermore, the establishment of over ten research centers and industry associations focused on hydrogen medicine has facilitated the ongoing progress of hydrogen molecular medicine within the country.

Seventeen organizations are engaged in the hydrogen health sector and hydrogen medicine research institutions.

1. **Hydrogen Molecular Biomedical Branch of the China International Healthcare Exchange Promotion Association**  
The Hydrogen Molecular Biomedical Branch of the China International Healthcare Exchange Promotion Association is a national social organization operating under the supervision of the China International Healthcare Exchange Promotion Association, commonly referred to as the China Medical Promotion Association Hydrogen Molecular Biomedical Branch. Established on March 19, 2014, in Beijing, this branch actively collaborates with a diverse array of biomedical, medical, research, and other enterprises and institutions, as well as experts, scholars, researchers, and practitioners committed to advancing hydrogen molecular biomedicine in China. This initiative aligns with national laws, regulations, and pertinent policies within the healthcare sector, with the overarching aim of leveraging collective strengths to foster the robust development of hydrogen molecular biomedicine in the country. The branch has organized numerous academic conferences focused on this field.

2. **Hydrogen Medicine Health Industry Branch of the National Health Industry Enterprise Management Association**  
Founded in 2017, the Hydrogen Medicine Health Industry Branch of the National Health Industry Enterprise Management Association serves as a secondary branch dedicated to the advancement of the hydrogen medicine health industry. Its mission is to promote and facilitate the development of the national hydrogen medicine health sector while fostering close collaboration among industry, academia, and research entities.

3. **Hydrogen Molecular Biomedical Professional Committee of the China-Japan Medical Technology Exchange Association**  
In October 2016, the Hydrogen Molecular Biomedical Professional Committee of the China-Japan Medical Technology Exchange Association was established at the Fudan University Academic Exchange Center, marking the inception of the first medical expert organization focused on the research and application of hydrogen molecular medicine.

4. **Beijing Hydrogen Molecular Research Center**  
The Beijing Hydrogen Molecular Research Center was officially inaugurated in 2017, spearheaded by Professor Ma Xuemei, a leading figure in hydrogen biology research in China, along with her team. The center operates under the auspices of the Hydrogen Molecular Biomedical Branch of the China Medical Promotion Association and is organized by the Institute of Life Science and Bioengineering at Beijing University of Technology.

5. **Beijing Hydrogen Molecular Research Center**  
The Beijing Hydrogen Molecular Research Center was officially inaugurated in 2017, spearheaded by Professor Ma Xuemei, a leading figure in hydrogen biology research in China, along with her team. The center operates under the auspices of the Hydrogen Molecular Biomedical Branch of the China Medical Promotion Association and is organized by the Institute of Life Science and Bioengineering at Beijing University of Technology.

6. **International Hydrogen Medicine and Biology Society**  
In December 2017, a preparatory meeting for the International Hydrogen Medicine and Biology Society was successfully convened in Foshan, Guangdong, with participation from experts and scholars from China, Japan, South Korea, as well as Europe and the United States. Qin Shucun was elected as the chairman, with Ota Naruo and Sun Xuejun serving as honorary chairmen, Li Kui and Noda Momomi as vice chairmen, and Song Guohua as the secretary-general. The expert group proposed the establishment of an annual international hydrogen biomedicine conference, rotating among member countries as hosts. The formation of the International Hydrogen Medicine and Biology Society signifies a novel integration mechanism and communication platform within the hydrogen biomedicine sector, significantly enhancing academic direction, innovation, quality, and exchange. It also plays a crucial role in advancing the standardization and normalization of the global hydrogen medicine industry, promoting healthy development, and expediting the translation of research findings in the field of hydrogen medicine.

7. **Hydrogen Science Center of Shanghai Jiao Tong University**  
Established in June 2018 with the support of the Shanghai municipal government, the Hydrogen Science Center of Shanghai Jiao Tong University serves as a comprehensive research platform encompassing energy and life sciences. It is recognized as the first interdisciplinary platform in China dedicated to research in hydrogen energy, hydrogen medicine, and hydrogen agriculture. The center officially commenced operations in January 2019 and established the "Hydrogen Science and Technology Alliance." Academician Ding Wenjiang of the Chinese Academy of Engineering serves as the director. The center has produced a substantial volume of academic papers and monographs in the fields of hydrogen medicine and hydrogen agriculture, achieving a prominent position in global citation rates.

8. **Taishan Hydrogen Biomedical Research Institute**  
On March 23, 2019, the Taishan Hydrogen Biomedical Research Institute of Shandong First Medical University was officially completed. This initiative was collaboratively launched by Professor Qin Shucun of the Taishan Hydrogen Biomedical Research Institute and Professor Sun Xuejun of the Navy Medical University, with support from various experts and scholars in hydrogen biomedicine and leading enterprises utilizing hydrogen technology. The institute features China's first hydrogen technology exhibition hall and the world's inaugural true hydrogen biomedicine popular science display base.

9. **Hydrogen Molecular Medicine Research Center of Xi'an Jiaotong University**  
The Mitochondrial Biomedical Research Institute at Xi'an Jiaotong University boasts an internationally recognized research platform in mitochondrial biology and medicine, actively engaging in global research on mitochondrial and free radical biomedicine. In 2019, Liu Jiankang, the dean of the School of Life Science and Technology and director of the Mitochondrial Biomedical Research Institute, and his team initiated plans to establish the Hydrogen Molecular Medicine Research Center at Xi'an Jiaotong University. They hosted the 6th China Hydrogen Biology and Hydrogen Medicine Academic Conference and the International Hydrogen Medicine and Hydrogen Biology Academic Conference in October 2019.

10. **Hydrogen Molecular Health Branch of the Shandong Health Technology Association**  
The Hydrogen Molecular Health Branch of the Shandong Health Technology Association was established in June 2019 in Jinan, Shandong, following approval from the Shandong Health Technology Association.

11. **Hydrogen Molecular Biomedical Branch of the China Geriatric Health Medicine Research Association**  
The Hydrogen Molecular Biomedical Branch of the China Geriatric Health Medicine Research Association was jointly established by experts and scholars in hydrogen biomedicine and geriatric medicine from various institutions, including Shandong First Medical University, the PLA General Hospital, the Navy Medical University, Beijing University of Technology, Shenzhen University, Nanjing Agricultural University, Xi'an Jiaotong University, Harbin Medical University, and China Medical University. This branch received approval from the China Geriatric Health Medicine Research Association (National Health Research Document [2020] No. 10) and was officially established as a national secondary academic branch on November 29, 2020, located at Shandong First Medical University.

12. **Hydrogen Medicine Professional Committee of the Wuxi Nutrition and Health Association**  
In May 2021, the Hydrogen Medicine Professional Committee of the Wuxi Nutrition and Health Association was established, coinciding with the inaugural ceremony and the first Hydrogen Medicine and Health Forum. The committee comprises relevant experts, scholars, and entrepreneurs from the health sector in Wuxi, collaborating to explore valuable clinical applications of hydrogen molecules in medicine. Its objective is to contribute to the medical transformation of hydrogen medicine and its clinical application and promotion in Wuxi, thereby supporting the "Healthy Wuxi" initiative.

13. **Hydrogen Medicine Professional Committee of the Guangdong Provincial Geriatric Health Association**  
Established in August 2021, the Hydrogen Medicine Professional Committee of the Guangdong Provincial Geriatric Health Association successfully convened the Greater Bay Area Hydrogen Medicine Summit Forum. This event attracted numerous scholars, professors, research leaders, clinical research experts, and practitioners in the field of hydrogen molecular biomedicine, facilitating in-depth discussions on critical topics related to hydrogen medicine and the health and wellness of the elderly.


Reasons to Select the H2yunshen Brand Molecular Hydrogen Water Bottle X5


H2HUBB Approved Level 4 Molecular Hydrogen Water Bottle X5

Link: https://h2hubb.com/products/x5hydrogenwaterbottle/


"The X5 Hydrogen Water Bottle is a Level 4 Hydrogen water generator with a high concentration, producing approximately 5.34 ppm of molecular hydrogen per cycle, as confirmed by H2HUBB laboratory testing. Designed for daily use and portability, the X5 aids in reducing oxidative stress, promoting cellular repair, and enhancing natural energy levels. Its advanced electrolysis technology, compact design, and premium aesthetics make it a dependable choice for individuals seeking antioxidant-rich hydration, whether at home, in the gym, or while traveling. Whether your goal is to optimize wellness, accelerate recovery, or improve hydration, the X5 delivers certified performance in a sleek and durable format."

Tyler W. LeBaron, the founder of the science-based nonprofit organization, the Molecular Hydrogen Institute, is recognized as a leading authority on molecular hydrogen and its associated benefits. His insights, along with those of numerous researchers from esteemed universities worldwide, provide valuable knowledge regarding this subject. herebelow some words is from Dr Tyler Lebaron's voice on Youtube published.

Molecular hydrogen (H2) serves as a highly effective selective antioxidant. This characteristic is significant, as many conventional antioxidants, such as vitamins C and E, lack selectivity and, when consumed in excess, may yield counterproductive effects. 

Key attributes of molecular hydrogen include:

- H2 functions as a selective antioxidant, meaning it does not excessively neutralize free radicals to the extent that it disrupts the body's oxidative balance.
- The H2 molecule is the smallest known molecule in the universe, enabling it to permeate all cellular membranes, including the blood-brain barrier and various subcellular compartments, such as mitochondria. Its lack of charge and polarity further enhances its bioavailability.
- H2 effectively interacts with the highly reactive hydroxyl radical, the most oxidative radical present in the body, converting it into harmless water.
- The application of hydrogen may prove beneficial in instances of heart attack or stroke, as it offers protection against oxidative damage caused by hydroxyl radicals during reperfusion.
- Additionally, hydrogen plays a role in regulating autophagy, mTOR, and IGF-1, adjusting their levels as necessary—either increasing them when required or decreasing them when they become excessive


Product Benefits


Product Advantages: 

- Produces approximately 5.34 parts per million (ppm) of hydrogen-rich water, achieving a performance level of 4 in hydrogen generation.
- Purity and yield have been rigorously tested and validated by H2HUBB.
- Mitigates oxidative stress and aids in maintaining cellular redox balance.
- Facilitates increased energy production at the mitochondrial level.
- Supports accelerated recovery for athletes and individuals engaged in physical activities.
- Effectively targets detrimental free radicals while preserving healthy cells.
- Features a compact and portable design suitable for daily use.
- Non-toxic, drug-free, and safe for ongoing hydration support.
- Improves hydration and nutrient transport to cells.
- Constructed from durable, eco-friendly materials, and designed as a reusable water bottle system.


Target User

- Individuals who prioritize their health and are seeking a portable solution for high-yield hydrogen.
- Athletes and fitness enthusiasts who require assistance with antioxidants and hydration.
- Biohackers dedicated to improving energy levels, recovery, and redox performance.
- Travelers and professionals in need of reliable daily access to hydrogen-enriched water.
- Consumers who place a premium on clinical validation, safety, and a compact design.


IHSA Certification

Pass US. EPA 200.7/200.8/300.0, 6010B, LVVWD

Pass US. EPA 537.1,PFAS Standard

Pass  IHSA Standard


H2 Analytics Tested Result

(5 Min Cycle: 2.42ppm, 10 Min: 5.06ppm,; 15 min: 6.891ppm )



SGS Las Vegas PFAS Test

(Full 18 Parametes tested,PFOA,PFOS, PFAS Non Detected)


SGS Las Vegas Water Quality Summary

(Full 35 parametes tested , Non Harmful Heavy Metal Detected)


H2HUBB Level 4 Approved Test Results





Product Parameter:

Material

SGS Tested Food Grade PC(Tritan)

Aviation Aluminum Alloy Shell

Proton Membrane

Dupond N117,Φ30

Water Electrolysis

SPE, PEM Technology


Hydrogen Concentration

5Min: 2.42 ppm,

10 Min 5.06ppm

15 Min: max 6.891ppm

(H2 Analytics Test Report)

(Reference Only)

Color

Gray, Pink, Gold

Power/Battery

Working Power: 1.5-3W

Charging Voltage: 5V 1A

Battery: 1800 mah li-battery

Capacity Size

230ml, Φ60*188


Packing

High-end Gift Packing,

30*21*18mm 990g

Product Card (E-User Manual)

3* USB Cable with Magnetic Charging

Warranty


1 Year or 3000 hours who is to reach



Different Piece Order Links

Please be advised that the above links accommodate orders of up to 5 units and facilitate dropshipping without any issues. 

- If you require 3 pieces, please click on this link: 

- If you wish to order 2 pieces, we recommend using this link: 

- If you need only 1 piece, kindly click on this link: 

**Statement:**

Research on hydrogen-rich water remains in its nascent stages. The promotion and utilization of hydrogen-rich water necessitate further examination, particularly due to the insufficient sample support currently available. The advancement of hydrogen medicine is expected to expedite this process. However, it is crucial to recognize that while hydrogen-rich water has demonstrated antioxidant and anti-inflammatory properties in laboratory and animal studies, the clinical evidence involving human subjects is still limited. Consequently, the therapeutic effects of hydrogen-rich water should not be equated with established medical treatments. The medical community requires additional insights from experts in hydrogen medicine to facilitate progress in this area. 

Moreover, it is important to note that hydrogen-rich water does not function as a universal antioxidant; rather, its efficacy lies in its selective ability to combat harmful free radicals, resulting in variable effects on the human body. Some individuals have reported chronic health improvements after several months of use, while others have experienced benefits for chronic conditions, particularly related to skin and intestinal health, after one or more years of consumption. These improvements should not be classified as medical treatments, as definitive conclusions necessitate further expert discussions in hydrogen medicine. This particular brand of hydrogen-rich water presents an option for antioxidant use in a home setting. However, individuals considering it for therapeutic purposes are advised to consult their healthcare provider.

Currently, there is insufficient research to provide clear conclusions regarding the concurrent use of hydrogen-rich water and medications. It is advisable to avoid direct mixing and consumption during medication use, prioritizing adherence to medical guidance. The antioxidant properties of hydrogen-rich water (water infused with dissolved hydrogen gas) may influence the metabolism of certain medications, yet the specific interaction mechanisms require further scientific validation.

** Risk Analysis of Concurrent Use of Hydrogen-Rich Water and Medications**

**Potential Interference with Drug Absorption:**
1. The antioxidant properties of hydrogen may alter the gastric acid environment or gut microbiota, potentially affecting the solubility or absorption efficiency of certain medications. For instance:
   - Medications that necessitate an acidic environment for optimal absorption (such as iron supplements and certain antibiotics) may exhibit diminished efficacy due to gastric acid neutralization.
   - Extended-release medications may experience irregular release profiles due to alterations in the intestinal environment.

**Specific Drug Metabolism Risks:**
2. Hydrogen may impact medications metabolized by liver enzymes (such as anticoagulants and immunosuppressants) by modulating oxidative stress responses. Animal studies suggest that hydrogen may enhance cytochrome P450 enzyme activity; however, human research data remains insufficient, indicating a theoretical risk.

**Differences in Drug Types:**
3. Prescription medications (such as antihypertensives and antidiabetics) require strict adherence to prescribed instructions and should not be consumed with hydrogen-rich water.
   - Over-the-counter medications (such as vitamins and probiotics) are recommended to be taken 1-2 hours apart from hydrogen-rich water.
   - Chemotherapy agents: Due to safety concerns, mixing with hydrogen-rich water is explicitly prohibited.

**2. Recommendations for Safe Medication Use**

**Consult a Healthcare Professional:**
1. If you regularly consume hydrogen-rich water and require medication (such as for chronic disease management), it is essential to inform your healthcare provider to evaluate individual risks.

**Time Interval Method:**
2. It is advisable to refrain from consuming hydrogen-rich water for one hour before and after taking medications to minimize potential interference with drug absorption.

**Adhere to Medication Instructions:**
3. Certain medications explicitly state "take only with plain water" or "avoid taking with carbonated liquids," and these instructions must be strictly followed.

**3. Scientific Understanding of Hydrogen-Rich Water**

**Controversy Regarding Efficacy:**
1. The antioxidant and anti-inflammatory effects of hydrogen-rich water are primarily supported by cellular or animal studies, with limited clinical evidence in humans, and individual responses may vary.

**Safety Considerations:**
2. Hydrogen, as a small molecular substance, has not demonstrated significant toxic side effects at regular consumption levels; however, long-term effects warrant further observation.

**Conclusion:**
During medication use, the efficacy and safety of the prescribed treatment should take precedence to avoid introducing unknown risks associated with the consumption of hydrogen-rich water. If consumption is deemed necessary, it is advisable to space it out from medication intake and consult a healthcare provider. Hydrogen-rich water should not be relied upon as a substitute for formal medical treatments.

#H2yunshen

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