Molecular Hydrogen Therapy

The Potential Benefits of Molecular Hydrogen Therapy

⏺︎What is Free Radicals

Free radicals, also referred to as free radical species, are defined as atoms or groups of atoms possessing unpaired electrons. These entities are generated when the covalent bonds within a compound's molecules break evenly due to external influences such as light or heat. In scientific notation, a dot (·) is typically placed adjacent to the atomic or group symbol to signify the presence of unpaired electrons. Notable examples of free radicals include the hydrogen radical (H·), which represents a hydrogen atom; the chlorine radical (Cl·), indicative of a chlorine atom; the hydroxyl radical (OH·); the methyl radical (CH3·); and the tetramethylpiperidine N-oxide radical, among others.

"Free radicals" are byproducts generated during the metabolic process of oxygen within the human body. These substances are characterized by their high reactivity, enabling them to engage in vigorous interactions with various materials. As unstable entities, free radicals possess the potential to inflict cellular damage, which can contribute to the onset of diseases and the aging process. In response to the presence of pathogens such as bacteria, fungi, or viruses, the immune system activates phagocytic cells to mount a defense. These phagocytic cells, through the action of specific enzymes, generate "superoxide anion free radicals" to target and eliminate the offending microorganisms or infected cells. Thus, a certain level of free radicals is essential for the body's defense mechanisms against diseases. Ideally, the concentration of free radicals within the human body should be maintained in a state of equilibrium.

However, exposure to various environmental stressors, including ultraviolet radiation, electromagnetic fields, tobacco smoke, pesticides, air pollution, as well as lifestyle factors such as irregular habits and psychological stress, can lead to an overproduction of free radicals, also referred to as oxidants. When the quantity of free radicals surpasses the normal defensive threshold, a "free radical chain reaction" may ensue, resulting in the oxidation of fundamental cellular components such as proteins, carbohydrates, and lipids. This process generates additional free radicals, which perpetuate the cycle of oxidation, ultimately compromising cellular integrity and function, and contributing to the development of various diseases.

While proteins in the body can facilitate the repair of damage inflicted by free radicals, cellular fatigue may hinder the effective elimination of these reactive species and the clearance of oxidative waste products. As a result, cumulative damage may manifest in symptoms associated with organ aging, physical decline, skin laxity, and diminished immune function.

⏺︎Harmful of Free Radicals

Research within the medical field has identified eight mechanisms through which excessive free radicals can inflict oxidative damage on the body:

1. Inducing breaks in DNA strands or altering base structures, thereby damaging genetic material.

2. Causing lipid peroxidation through the destruction of unsaturated fatty acids.

3. Oxidizing protein molecules and inactivating serum anti-proteases by affecting internal enzymes.

4. Provoking abnormal responses in mononuclear leukocytes and macrophages, leading to the release of inflammatory mediators and the initiation of inflammatory processes.

5. Compromising periodontal tissues by degrading osteoclasts and the bone matrix at the bone interface.

6. Resulting in cellular deterioration, deformation, and death through lipid oxidation, which accelerates the aging of tissues and organs.

7. Directly affecting the cell nucleus, potentially causing gene mutations that may lead to cancer.

8. Inflicting damage on vital organs such as the heart, liver, and lungs, as well as on blood vessels.

⏺︎Molecular hydrogen (H2) serves as a highly effective selective antioxidant

Hydrogen gas (H2) has the capability to selectively eliminate certain toxic reactive oxygen species (ROS), including hydroxyl radicals (•OH) and peroxynitrite anions (ONOO-), while leaving unaffected those ROS that exert physiological effects, such as hydrogen peroxide (H2O2) and nitric oxide (NO-).

Molecular Hydrogen Therapy

In the span of 13 years dedicated to the research of molecular hydrogen, over 2,000 scientific articles have been published regarding the health benefits associated with various methods of hydrogen consumption. Notably, there are more than 120 publications focused on human trials that investigate hydrogen as a therapeutic agent. The efficacy of hydrogen therapy has been demonstrated across all mammalian organs in over 170 trials.

Among the 128 publications pertaining to hydrogen therapy in humans, the predominant focus—68 articles—addresses the consumption of hydrogen-infused water. Hydrogen inhalation follows as the second most studied method, with 25 publications, while hydrogen-rich saline ranks third with 11 publications. Topical hydrogen therapy has been discussed in ten publications, eight of which specifically examine hydrogen water bathing. Additionally, three publications explore a product designed to generate hydrogen gas within the body, including two studies on hydrogen tablets and one on the drug acarbose, along with several other methods. This results in a total of 130 distinct administration methods, as two publications utilized multiple delivery methods for hydrogen therapy.

Out of the 124 human trials conducted, four did not demonstrate a benefit; however, 120 trials did, yielding a success rate of 97% for molecular hydrogen therapy. It is important to note that none of the trials indicating a benefit have reached the phase III multicenter trial stage, although many are randomized, double-blind, placebo-controlled studies classified as phase I or phase II. Consequently, definitive conclusions regarding the efficacy of hydrogen therapy for specific indications cannot yet be drawn. Furthermore, the literature reveals significant variability in the established dosing, delivery methods, and timing of consumption for hydrogen therapy across different indications.

Professor Naruo Ohta of Nippon Medical University has conducted research that substantiates the selective antioxidant properties of hydrogen. His findings indicate that hydrogen can effectively and selectively neutralize detrimental free radicals, which are implicated in various diseases and the aging process. This mechanism contributes to the maintenance of internal environmental equilibrium at the fundamental cellular fluid level within the human body, stimulates the body's intrinsic self-repair processes, and enhances overall health outcomes.

Molecular Hydrogen therapy, leveraging its selective attenuation of hydroxyl radicals (˙OH) and ONOO−, has emerged as a pivotal pathophysiological modulator with antioxidant, anti-inflammatory, and antiapoptotic attributes. Hydrogen therapy has been extensively studied both preclinically and clinically, especially in diseases with an inflammatory nature

Molecular Hydrogen Research In China

Since 2007, the field of hydrogen medicine has experienced significant global advancement, with China being a notable contributor. According to preliminary data, there are over a thousand researchers in China dedicated to the study of hydrogen medicine, including more than ten academicians from the Chinese Academy of Sciences and the Chinese Academy of Engineering. Additionally, there are over 80 projects funded by the National Natural Science Foundation that pertain to hydrogen medicine. On an international scale, more than 1,800 scholarly articles have been published in this domain, with nearly half originating from China. Furthermore, the establishment of over ten research centers and industry associations focused on hydrogen medicine has facilitated the ongoing progress of hydrogen molecular medicine within the country.

Molecular Hydrogen Reasearch organizations are engaged in the hydrogen health sector and hydrogen medicine research institutions.

1. **Hydrogen Molecular Biomedical Branch of the China International Healthcare Exchange Promotion Association**

The Hydrogen Molecular Biomedical Branch of the China International Healthcare Exchange Promotion Association is a national social organization operating under the supervision of the China International Healthcare Exchange Promotion Association, commonly referred to as the China Medical Promotion Association Hydrogen Molecular Biomedical Branch. Established on March 19, 2014, in Beijing, this branch actively collaborates with a diverse array of biomedical, medical, research, and other enterprises and institutions, as well as experts, scholars, researchers, and practitioners committed to advancing hydrogen molecular biomedicine in China. This initiative aligns with national laws, regulations, and pertinent policies within the healthcare sector, with the overarching aim of leveraging collective strengths to foster the robust development of hydrogen molecular biomedicine in the country. The branch has organized numerous academic conferences focused on this field.

2. **Hydrogen Medicine Health Industry Branch of the National Health Industry Enterprise Management Association**

Founded in 2017, the Hydrogen Medicine Health Industry Branch of the National Health Industry Enterprise Management Association serves as a secondary branch dedicated to the advancement of the hydrogen medicine health industry. Its mission is to promote and facilitate the development of the national hydrogen medicine health sector while fostering close collaboration among industry, academia, and research entities.

3. **Hydrogen Molecular Biomedical Professional Committee of the China-Japan Medical Technology Exchange Association**

In October 2016, the Hydrogen Molecular Biomedical Professional Committee of the China-Japan Medical Technology Exchange Association was established at the Fudan University Academic Exchange Center, marking the inception of the first medical expert organization focused on the research and application of hydrogen molecular medicine.

4. **Beijing Hydrogen Molecular Research Center**

The Beijing Hydrogen Molecular Research Center was officially inaugurated in 2017, spearheaded by Professor Ma Xuemei, a leading figure in hydrogen biology research in China, along with her team. The center operates under the auspices of the Hydrogen Molecular Biomedical Branch of the China Medical Promotion Association and is organized by the Institute of Life Science and Bioengineering at Beijing University of Technology.

5. **Beijing Hydrogen Molecular Research Center**

6. **International Hydrogen Medicine and Biology Society**

In December 2017, a preparatory meeting for the International Hydrogen Medicine and Biology Society was successfully convened in Foshan, Guangdong, with participation from experts and scholars from China, Japan, South Korea, as well as Europe and the United States. Qin Shucun was elected as the chairman, with Ota Naruo and Sun Xuejun serving as honorary chairmen, Li Kui and Noda Momomi as vice chairmen, and Song Guohua as the secretary-general. The expert group proposed the establishment of an annual international hydrogen biomedicine conference, rotating among member countries as hosts. The formation of the International Hydrogen Medicine and Biology Society signifies a novel integration mechanism and communication platform within the hydrogen biomedicine sector, significantly enhancing academic direction, innovation, quality, and exchange. It also plays a crucial role in advancing the standardization and normalization of the global hydrogen medicine industry, promoting healthy development, and expediting the translation of research findings in the field of hydrogen medicine.

7. **Hydrogen Science Center of Shanghai Jiao Tong University**

Established in June 2018 with the support of the Shanghai municipal government, the Hydrogen Science Center of Shanghai Jiao Tong University serves as a comprehensive research platform encompassing energy and life sciences. It is recognized as the first interdisciplinary platform in China dedicated to research in hydrogen energy, hydrogen medicine, and hydrogen agriculture. The center officially commenced operations in January 2019 and established the "Hydrogen Science and Technology Alliance." Academician Ding Wenjiang of the Chinese Academy of Engineering serves as the director. The center has produced a substantial volume of academic papers and monographs in the fields of hydrogen medicine and hydrogen agriculture, achieving a prominent position in global citation rates.

8. **Taishan Hydrogen Biomedical Research Institute**

On March 23, 2019, the Taishan Hydrogen Biomedical Research Institute of Shandong First Medical University was officially completed. This initiative was collaboratively launched by Professor Qin Shucun of the Taishan Hydrogen Biomedical Research Institute and Professor Sun Xuejun of the Navy Medical University, with support from various experts and scholars in hydrogen biomedicine and leading enterprises utilizing hydrogen technology. The institute features China's first hydrogen technology exhibition hall and the world's inaugural true hydrogen biomedicine popular science display base.

9. **Hydrogen Molecular Medicine Research Center of Xi'an Jiaotong University**

The Mitochondrial Biomedical Research Institute at Xi'an Jiaotong University boasts an internationally recognized research platform in mitochondrial biology and medicine, actively engaging in global research on mitochondrial and free radical biomedicine. In 2019, Liu Jiankang, the dean of the School of Life Science and Technology and director of the Mitochondrial Biomedical Research Institute, and his team initiated plans to establish the Hydrogen Molecular Medicine Research Center at Xi'an Jiaotong University. They hosted the 6th China Hydrogen Biology and Hydrogen Medicine Academic Conference and the International Hydrogen Medicine and Hydrogen Biology Academic Conference in October 2019.

10. **Hydrogen Molecular Health Branch of the Shandong Health Technology Association**

The Hydrogen Molecular Health Branch of the Shandong Health Technology Association was established in June 2019 in Jinan, Shandong, following approval from the Shandong Health Technology Association.

11. **Hydrogen Molecular Biomedical Branch of the China Geriatric Health Medicine Research Association**

The Hydrogen Molecular Biomedical Branch of the China Geriatric Health Medicine Research Association was jointly established by experts and scholars in hydrogen biomedicine and geriatric medicine from various institutions, including Shandong First Medical University, the PLA General Hospital, the Navy Medical University, Beijing University of Technology, Shenzhen University, Nanjing Agricultural University, Xi'an Jiaotong University, Harbin Medical University, and China Medical University. This branch received approval from the China Geriatric Health Medicine Research Association (National Health Research Document [2020] No. 10) and was officially established as a national secondary academic branch on November 29, 2020, located at Shandong First Medical University.

12. **Hydrogen Medicine Professional Committee of the Wuxi Nutrition and Health Association**

In May 2021, the Hydrogen Medicine Professional Committee of the Wuxi Nutrition and Health Association was established, coinciding with the inaugural ceremony and the first Hydrogen Medicine and Health Forum. The committee comprises relevant experts, scholars, and entrepreneurs from the health sector in Wuxi, collaborating to explore valuable clinical applications of hydrogen molecules in medicine. Its objective is to contribute to the medical transformation of hydrogen medicine and its clinical application and promotion in Wuxi, thereby supporting the "Healthy Wuxi" initiative.

13. **Hydrogen Medicine Professional Committee of the Guangdong Provincial Geriatric Health Association**

Established in August 2021, the Hydrogen Medicine Professional Committee of the Guangdong Provincial Geriatric Health Association successfully convened the Greater Bay Area Hydrogen Medicine Summit Forum. This event attracted numerous scholars, professors, research leaders, clinical research experts, and practitioners in the field of hydrogen molecular biomedicine, facilitating in-depth discussions on critical topics related to hydrogen medicine and the health and wellness of the elderly.

Molecular Hydrogen Research In USA

Tyler W. LeBaron, the founder of the science-based nonprofit organization, the Molecular Hydrogen Institute, Leaders in Molecular Hydrogen education & research,is recognized as a leading authority on molecular hydrogen and its associated benefits. His insights, along with those of numerous researchers from esteemed universities worldwide, provide valuable knowledge regarding this subject. herebelow some words is from Dr Tyler Lebaron's voice on Youtube published.

Molecular hydrogen (H2) serves as a highly effective selective antioxidant. This characteristic is significant, as many conventional antioxidants, such as vitamins C and E, lack selectivity and, when consumed in excess, may yield counterproductive effects.

Key attributes of molecular hydrogen include:

- H2 functions as a selective antioxidant, meaning it does not excessively neutralize free radicals to the extent that it disrupts the body's oxidative balance.

- The H2 molecule is the smallest known molecule in the universe, enabling it to permeate all cellular membranes, including the blood-brain barrier and various subcellular compartments, such as mitochondria. Its lack of charge and polarity further enhances its bioavailability.

- H2 effectively interacts with the highly reactive hydroxyl radical, the most oxidative radical present in the body, converting it into harmless water.

- The application of hydrogen may prove beneficial in instances of heart attack or stroke, as it offers protection against oxidative damage caused by hydroxyl radicals during reperfusion.

- Additionally, hydrogen plays a role in regulating autophagy, mTOR, and IGF-1, adjusting their levels as necessary—either increasing them when required or decreasing them when they become excessive

Testing and Certification Services for Hydrogen Water Products

H2 Analytics is a US-based company approved by the International Hydrogen Standards Association (IHSA) for testing and certifying the hydrogen performance (H2) and water quality of hydrogen water products. Using gas chromatography (currently the only IHSA-authorized method), we can test the concentration of hydrogen water produced by virtually any type of hydrogen water technology.

Molecular Hydrogen Therapy Device Evaluation Service

H2HUBB is your trusted authority for all things hydrogen therapy—combining education, third-party product testing, and honest recommendations under one roof.

International Hydrogen Standards Association (IHSA)

IHSA is an international organization focused on determining the standards for measuring hydrogen gas, and establishing guidelines for its therapeutic use.

Molecular Hydrogen Therapy benefits reviews for Athletic Performance, Recovery, and Athlete Health

Article Published in 2024

Hydrogen-Rich Water to Enhance Exercise Performance: A Review of Effects and Mechanisms

Can molecular hydrogen supplementation reduce exercise-induced oxidative stress in healthy adults? A systematic review and meta-analysis

Effects of 8 days intake of hydrogen-rich water on muscular endurance performance and fatigue recovery during resistance training

Effect of hydrogen-rich gas on proprioception and muscle endurance after high-intensity exercise

Article Published in 2022

Short-Term Consumption of Hydrogen-Rich Water Enhances Power Performance and Heart Rate Recovery in Dragon Boat Athletes: Evidence from a Pilot Study

Hydrogen Rich Water Consumption Positively Affects Muscle Performance, Lactate Response, and Alleviates Delayed Onset of Muscle Soreness After Resistance Training

Effects of Intestinal Bacterial Hydrogen Gas Production on Muscle Recovery following Intense Exercise in Adult Men: A Pilot Study

Effects of pre-exercise H2 inhalation on physical fatigue and related prefrontal cortex activation during and after high-intensity exercise

Article Published in 2021

Effects of 7-day intake of hydrogen-rich water on physical performance of trained and untrained subjects

Application of Molecular Hydrogen as an Antioxidant in Responses to Ventilatory and Ergogenic Adjustments during Incremental Exercise in Humans

Effects of an H2-infused, Nitric Oxide-Producing Functional Beverage on Exercise and Cognitive Performance

Molecular Hydrogen Mitigates Performance Decrement during Repeated Sprints in Professional Soccer Players

Article Published in 2020

Case Report: Acute hydrotherapy with super-saturated hydrogen-rich water for ankle sprain in a professional athlete

Effects of electrolyzed hydrogen water ingestion during endurance exercise in a heated environment on body fluid balance and exercise performance

Hydrotherapy with hydrogen-rich water compared with RICE protocol following acute ankle sprain in professional athletes: a randomized non-inferiority pilot trial

The Effects Of Rich Hydrogen And Oxygen Mixed Gas Inhalation After High Intensity Exercise Influence On Exercise Performance

The Effects of Supersaturated Hydrogen-Rich Water Bathing on Biomarkers of Muscular Damage and Soreness Perception in Young Men Subjected to High-Intensity Eccentric Exercise

Hydrogen-rich water suppresses the reduction in blood total antioxidant capacity induced by 3 consecutive days of severe exercise in physically active males

Effects of 7-day intake of hydrogen-rich water on physical performance of trained and untrained subjects

Hydrogen-Rich Water Supplementation and Up-Hill Running Performance: Effect of Athlete Performance Level

Application of Molecular Hydrogen as a Novel Antioxidant in Sports Science

Two-week continuous supplementation of hydrogenrich water increases peak oxygen uptake during an incremental cycling exercise test in healthy humans

Article Published in 2019

Drinking hydrogen water enhances endurance and relieves psychometric fatigue: a randomized, double-blind, placebo-controlled study

Effects of the long-term consumption of hydrogen-rich water on the antioxidant activity and the gut flora in female juvenile soccer players from Suzhou, China

Acute Supplementation with Molecular Hydrogen Benefits Submaximal Exercise Indices. Randomized, Double-Blinded, Placebo-Controlled Crossover Pilot Study

Short-term H2 inhalation improves running performance and torso strength in healthy adults

Acute ingestion of hydrogen-rich water does not improve incremental treadmill running performance in endurance-trained athletes

Hydrogen Rich Water Improved Ventilatory, Perceptual and Lactate Responses to Exercise

Hydrogen gas: from clinical medicine to an emerging ergogenic molecule for sports athletes

Article Published in 2018

28-Days Hydrogen-Rich Water Supplementation Affects Exercise Capacity in Mid-Age Overweight Women

Article Published in 2017

Hydrogen-rich Water Modulates Redox Status Repeated Three Consecutive Days Of Strenuous Exercise.

Effects of hydrogen rich water on prolonged intermittent exercise

Article Published in 2016

Is molecular hydrogen beneficial to enhance post-exercise recovery in female athletes?

Molecular Hydrogen Affected Post-Exercise Recovery in Judo Athletes

Clinical Effects of Hydrogen Administration: From Animal and Human Diseases to Exercise Medicine

Article Published in 2015

Effectiveness of Oral and Topical Hydrogen for Sports-Related Soft Tissue Injuries

Molecular Hydrogen in Sports Medicine: New Therapeutic Perspectives

Article Published in 2012

Pilot study: Effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes

Statement:

Research on hydrogen-rich water remains in its nascent stages. The promotion and utilization of hydrogen-rich water necessitate further examination, particularly due to the insufficient sample support currently available. The advancement of hydrogen medicine is expected to expedite this process. However, it is crucial to recognize that while hydrogen-rich water has demonstrated antioxidant and anti-inflammatory properties in laboratory and animal studies, the clinical evidence involving human subjects is still limited. Consequently, the therapeutic effects of hydrogen-rich water should not be equated with established medical treatments. The medical community requires additional insights from experts in hydrogen medicine to facilitate progress in this area.

Moreover, it is important to note that hydrogen-rich water does not function as a universal antioxidant; rather, its efficacy lies in its selective ability to combat harmful free radicals, resulting in variable effects on the human body. Some individuals have reported chronic health improvements after several months of use, while others have experienced benefits for chronic conditions, particularly related to skin and intestinal health, after one or more years of consumption. These improvements should not be classified as medical treatments, as definitive conclusions necessitate further expert discussions in hydrogen medicine. This particular brand of hydrogen-rich water presents an option for antioxidant use in a home setting. However, individuals considering it for therapeutic purposes are advised to consult their healthcare provider.

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